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Gene expression analysis of functionally defined LSC revealed that these cells harbor a transcriptional profile related to HSC and that stemness-related gene expression programs are highly predictive of response to standard AML therapy

Standardization of Senescence Biomarkers: A major challenge in both the development and application of senescence-targeting therapies is the identification of reliable biomarkers that can accurately assess the presence of senescent cells and their effects.256 Current biomarkers for senescence, such as p16^INK4a, -galactosidase activity, and SASP factors, are useful in research settings, but their clinical applicability remains limited