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Published literature repeatedly references interactions involving nitric oxide pathways, angiogenic signaling, fibroblast activity, collagen organization, endothelial repair, oxidative stress modulation, and neurotransmitter systems

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Positron emission tomography (PET) is a non-invasive, in vivo imaging modality, with high sensitivity to detect active arthritis both at early or advanced stages of RA [31, 32]

doi:10.1038/nrm3028 pmid:21179058 Zhang T, Tsutsuki H, Islam W, Ono K, Takeda K, Akaike T, Sawa T (2021) ATP exposure stimulates glutathione efflux as a necessary switch for NLRP3 inflammasome activation