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149 Charge of K65 (positive charge) in Claudin-1, E158 (negative charge) in Claudin-3, and the polarity of Q56 and Q62 in Claudin-3 and Q57 in Cldn5 are required for establishing tight junction strands

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This is in concordance with past evidence noting significant degradation of full-length tubulin- with increased post-mortem interval in human brain, as well as similar findings noted in other biological samples such as bone and skeletal muscle 37,38

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Engineered solely for preclinical investigations, each batch of Dihexa undergoes a comprehensive quality assessment and includes complete documentation, including a Certificate of Analysis (COA), purity data, and structural verification