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NO reacts with superoxide anion (O 2 ) to form a stronger oxidant identified as peroxynitrite anion (ONOO )

PubMed CrossRef Bertilsson L

[1] [2] However, longstanding neurological complications, such as peripheral neuropathy or cognitive changes, may require three to six months of consistent treatment before significant improvement occurs, and some damage may be irreversible if treatment is delayed

Wheatcroft SB, Kearney MT, Shah AM, Ezzat VA, Miell JR, Modo M, Williams SCR, Cawthorn WP, Medina-Gomez G, Vidal-Puig A, Sethi JK, Crossey PA

What comparative research designs are used to distinguish independent versus combined effects of these two compounds