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T cells, particularly Th2 cells, provide co-stimulatory signals by binding CD40L on their surface to CD40 on B cells, promoting B cell differentiation into plasma cells and antibody production (147)

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While oral absorption is limited for B12, taking very high doses (e.g., 1000mcg or 2000mcg) can allow for a small amount of passive absorption that doesnt rely on intrinsic factor