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Unlike full-length erythropoietin, ARA-290: Does not bind the classical erythropoietin receptor responsible for red blood cell production Does not increase hematocrit Does not stimulate bone marrow erythropoiesis Instead, it selectively activates anti-inflammatory and cytoprotective pathways

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[DOI] [PMC free article] [PubMed] [Google Scholar] 591.Ning J., Huai J., Wang S., Yan J., Su R., Zhang M., Liu M., Yang H

Coppola, G