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The affective aspect of pain is still not well-addressed, so there is a strong need to study the affective component of pain in animal models [182]

Figure 2 shows a representative image that was analyzed using the AI analysis tool

Whether these discrepancies arise from insufficient subtype selectivity of compounds with activity at TRP channels, compensatory expression changes in knockout animals, or difference between animal models, remains to be determined

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Clinical trials and meta-analyses indicate improvements in ventricular function and reductions in mortality, arrhythmias, and angina