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These findings indicate that the action of endogenous leptin is intact in mice with DIO despite hyperleptinaemia and resistance to exogenous leptin, thus challenging the view that leptin no longer suppresses food intake and reduces body weight in obesity

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It can be used during an energy crisis, i.e., reduced blood supply and/or aglycemia but recent studies have provided evidence that glycogen is a highly dynamic molecule which via the glycogen-shunt (Figure 7) channels a significant part of the glucose carbon entering the brain into glycolysis (79, 80)

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Stroup DF, Berlin JA, Morton SC, Olkin I, Williamson GD, Rennie D, Moher D, Becker BJ, Sipe TA, Thacker SB: Meta-analysis of observational studies in epidemiology: a proposal for reporting

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