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In both cases, the relatively low internalization rate shown in CLSM and FACS indicated that internalization is metabolically driven rather than passive 36
Losing the glutamate at position 3 sharply reduces its binding to IGF-binding proteins, which is why in cell culture it is reported to be roughly ten times more potent than intact IGF-1 at driving cell proliferation and hypertrophy [1]
Lastly, we applied the methodology to peptide nucleic acids (PNAs)
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doi: 10.1042/BJ20102007
