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The classic IV formula developed by Dr

Perry BI, Upthegrove R, Kappelmann N, Jones PB, Burgess S, Khandaker GM

Transformation to a predominantly AR-negative PCa with increasing NE differentiation may be an important resistance mechanism in castration-resistant disease, and indeed may be more common than was previously recognised

Conjugation of metabolites to GSH may be important in biosynthetic and catabolic pathways (Dixon and Edwards, 2010)

This line was subsequently modified by moving the line to a 4-hour acetaminophen concentration of 150 mcg/mL (current US cutoff) to increase the safety margin for treatment decisions