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2017;83:e00737-17
Excess free iron, often resulting from inflammation-induced disruption of iron homeostasis, generates reactive oxygen species (ROS) through the Fenton reaction ( Figure 1 )
However, FMN has three states, the fully oxidized FMN, the semiquinone (FMNH) intermediate, and the fully reduced FMNH 2
[] DNA modification, respiratory chain dysfunction, the oxidation of lipids within cells and the deactivation of enzymes that are essential are all brought on by ROS
K., Zeybek, B., Santin, A
