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2.3 Cys, GSH, and GPX4 axis 2.3.1 Cys, GSH, and GPX4 axis in ferroptosis The Cys 2 /Glu antiporter system xc - , which is composed of two subunits SLC7A11 and SLC3A2, is needed to import cystine (Cys 2 ) into cells for subsequent GSH synthesis (6)

These hypoxic episodes are followed by rapid reoxygenation, which triggers a surge in the production of ROS through mechanisms such as mitochondrial dysfunction and activation of NADPH oxidase pathways (Stanek et al., 2021)

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