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In the years since Ozempic came to market, GLP-1 drugs have catapulted to stardom, becoming a multibillion-dollar industry with a surreal series of successes, first as an effective treatment for diabetes and then as a hit for weight loss

[DOI] [PubMed] [Google Scholar] 52.Bjerre Knudsen L., Madsen L.W., Andersen S., Almholt K., De Boer A.S., Drucker D.J., Gotfredsen C., Egerod F.L., Hegelund A.C., Jacobsen H., et al

Under pathological stress, macrophages contribute to inflammatory responses, which drive insulin resistance and T2DM

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Average decrease in HbA1c from baseline, the primary endpoint, over the 40-week period ranged from 1.7% to 2.0% across retatrutide doses and was 0.8% with placebo