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Conclusion This SLR and meta-analysis of real-world studies suggests that the combination of SGLT2is + GLP-1RAs is associated with significantly lower all-cause mortality than individual therapies, with an improvement in cardiovascular, renal, and glycemic measurements

The weight loss was dramaticfrom 89kg to 84kg in 2 weeks

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The One-Agent-at-a-Time Principle Incretin compounds are always introduced one at a time and titrated in steps typically starting low and increasing every four weeks specifically so tolerability and response can be attributed to a single variable