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Glucagon-like peptide-1 (GLP-1) agonist therapies are increasingly being used for type 2 diabetes and obesity, but evidence now shows they also reduce inflammation across multiple organs through mechanisms related and unrelated to weight-loss-driven metabolic improvements

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Furthermore, It complicates the physical assessment of HFpEF indicators: evaluation of jugular venous pressure, auscultation for lung rales, and assessment of peripheral edema

In addition to confirm comparable efficacy to injectables, oral small molecules need to show the beneficial cardiovascular effects seen with semaglutide

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