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In addition, post-hoc sensitivity analyses were performed by excluding the prediabetic population (SELECT trial [8]) in Fig

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A significant drug main effect ( p = 0.001), as well as a trend-level drug time-point interaction effect ( p = 0.08), was detected for GLP-1

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Neural pathway changes The brain reward circuitry changes in response to weight loss, making calorie-dense foods more rewarding and harder to resist

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