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While united by a common mechanism, these agents vary significantly in their molecular structure, size, and half-lifeproperties that may influence their ability to penetrate the blood-retinal barrier (BRB) (Table 1)

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Evidence Trials investigating the use of GLP-1 RAs currently approved in the United States in addition to basal insulin versus an active comparator of prandial insulin are summarized in TABLE 2

The practical protocols