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Mean change in HbA 1c from baseline to week 26 was 0.7 to 1.9% with increasing doses of oral semaglutide, 1.9% with once-weekly s.c

This can result in primary and secondary ACTH deficiency, especially during stressful situations

Genes encoding microfibril-associated and ECM-associated proteins are also generally downregulated in semaglutide-treated samples (except Dpt, Dcn, and F3, which are significantly upregulated)

Pre-clinical data demonstrate attenuation of inflammation, preservation of epithelial integrity, and modulation of the microbiome in colitis models