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The first phase 3 retatrutide trial, TRIUMPH-4, top-line data announced today Retatrutide, a triple GLP-1,GIP, glucagon agonist studied in patients with obesity and osteoarthritis 28.7% weight loss at 68 weeks Reduced key cardiometabolic risk markers non-HDL cholesterol, triglycerides, and hsCRP Highest dose lowered systolic BP by 14 mmHg Reduced WOMAC pain scores by up to an average of 4.5 points (75.8%) and significantly improved measures of physical function GI side effects most common adverse event We now await 7 additional phase 3 trials in other obesity related comorbidities

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trt nation semaglutide Maintenance therapy on or tirzepatide trt nation semaglutide TRT News

In a large, propensity scorematched cohort of adults with #HidradenitisSuppurativa, use of glucagon-like peptide-1 receptor agonists (#GLP1RA) was associated with lower all-cause mortality and major adverse cardiovascular events over 1- and 2-year follow-up compared to nonusers

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