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202 Firstly, DNA methylation regulates different insulin signaling genes, such as insulin ( INS ), insulin receptor substrate 1 ( IRS1 ), Insulin-like growth factor-1/2 (IGF-1/2), Insulin-like growth factor-binding protein 1/2 (IGFBP-1/2), phosphatidylinositol 3-kinase regulatory subunit (PIK3R1), and Glucagon-like peptide-1 receptor (GLP-1R)

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It carries a unique, compounding set of risks reduced patent term on new matter, the possibility that the parent application becomes prior art against its own child, and near-certain exposure to obviousness-type double patenting challenges that divisional applications are explicitly shielded from

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