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Semaglutide and other GLP-1 agonists work by activating receptors on pancreatic beta cells and in the brain to regulate appetite and blood sugar

Semaglutide and tirzepatide are injectable medications that support weight loss by regulating hunger and improving metabolic function: Semaglutide (Ozempic/Wegovy) : A GLP-1 receptor agonist that slows gastric emptying, reduces appetite, and helps manage blood sugar levels

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Challenges in MASH Drug Development Complexity of MASH MASH is a complex condition requiring treatments to address fat accumulation, inflammation, and fibrosis simultaneously

There are also other practical reasons to prescribe these drugs in people with type 2 diabetes, because all three classes are associated with relatively low risk of hypoglycemic events, while patients treated with GLP-1RA and SGLT-2 inhibitors may also benefit from weight loss [11]