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We therefore applied daf-2 RNAi to both mog-3(-) mutants and mog-3(-) mutants expressing DAF-16::GFP as a way to ectopically activate DAF-16

First, while the effects of fatty acids in vitro and hyperlipidaemia in vivo were consistently observed at the level of Glp1r expression and signalling, the decrease in Gipr was not seen in vitro, and normalisation of circulating lipid levels did not improve the efficacy of D-GIP in db/db mice