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This is the data behind the muscle-and-nutrient concern, drawn from the largest claims analysis to date , Butsch and colleagues' retrospective study of 461,382 US adults newly prescribed GLP-1RAs (Butsch et al., Obesity Pillars, 2025
Other conditions common in people with obesity or diabetes can also contribute to fatigue, including sleep apnoea, thyroid disorders, and depression
doi:10.1111/dom.13172 7
Many patients assume medication failure signals a personal failure or lack of discipline
These medications mimic a natural hormone to regulate appetite and promote fat loss
