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Conclusively, research on GLP-1R and its agonists marks a promising direction in metabolic disease therapy, extending their potential beyond glucose regulation and offering hope for more comprehensive approaches in addressing metabolic diseases

They include changes in the production of constricting and relaxing factors endothelium-derived, interruption of molecular signaling, increased oxidative stress, renal injury, insulin resistance, hyperinsulinemia, sleep apnea syndrome, that make hemodynamic alterations (108, 109)

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Side effects may include nausea or diarrhea