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GLP-1R works through the combination of the endogenous ligand Glucagon-like peptide-1 (GLP-1) or exogenous agonists, which activate multiple intracellular signaling pathways that enhance insulin secretion, inhibit glucagon secretion, protect -cells from apoptosis, delay gastric emptying and increase satiety

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Dart RJ, Zlatareva I, Vantourout P, et al

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Proper Storage Requirements to Extend Medication Life Semaglutide pens and vials must remain refrigerated at 3646F until first use, mimicking pharmacy storage conditions that preserve the peptide structure

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