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Chemical modifications such as lipidation (first applied therapeutically to insulin in the 1990s), PEGylation (established as a platform technology in the early 2000s), and reversible albumin binding have transformed peptides from short-lived signaling molecules into durable therapeutics suitable for weekly or even monthly administration ( In parallel, advances in formulation science and delivery technologies have expanded the feasible routes of peptide administration

Concentrations of Exendin-4-Fc were calculated using Watson LIMS v.7.3.0.01 (Thermo Scientific, Inc.)

Cell Metabolism 30976986.e3