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dpp 4 and glp 1 GLP-1 receptor agonists or DPP-4 inhibitors: How to guide the clinician? dpp-4_inhibitors [TUSOM | Pharmwiki]
Description
Peminda Cabandugama, MD, an endocrinologist and obesity medicine specialist at Cleveland Clinic in Ohio, found the results to be slightly surprising. The pharmacokinetics [how drugs move through the body] of GLP-1 medications show a half-life of 5 days, which means the current standard of using these medications every 7 days is also stretching this out, says Dr
![dpp 4 and glp 1 GLP-1 receptor agonists or DPP-4 inhibitors: How to guide the clinician? dpp-4_inhibitors [TUSOM | Pharmwiki]](https://tmedweb.tulane.edu/pharmwiki/lib/exe/fetch.php/dpp4.png?w=600&tok=f9724b)
Seeing how they showed up for the GLP-1 community
![dpp 4 and glp 1 GLP-1 receptor agonists or DPP-4 inhibitors: How to guide the clinician? dpp-4_inhibitors [TUSOM | Pharmwiki]](https://www.diabetesincontrol.com/wp-content/uploads/2011/10/www.diabetesincontrol.com_images_issues_2011_10_dpp4-figure1.png)
doi: 10.1038/s41598-017-09898-4 [DOI] [PMC free article] [PubMed] [Google Scholar] 27
![dpp 4 and glp 1 GLP-1 receptor agonists or DPP-4 inhibitors: How to guide the clinician? dpp-4_inhibitors [TUSOM | Pharmwiki]](https://ars.els-cdn.com/content/image/3-s2.0-B9780443291296000142-u02-01-9780443291296.jpg)
Multiple large-scale observational studies and peer-reviewed analyses published in 2025 and 2026 have contributed substantially to this field
![dpp 4 and glp 1 GLP-1 receptor agonists or DPP-4 inhibitors: How to guide the clinician? dpp-4_inhibitors [TUSOM | Pharmwiki]](https://www.frontiersin.org/api/ipx/w=1200&f=png/https://www.frontiersin.org/files/Articles/464622/fendo-10-00389-HTML/image_m/fendo-10-00389-g001.jpg)
Importantly, a substantial number of patients had multiple reasons noted for stopping (21%), underscoring the complexity of real-world medication use and the challenges patients face when using these therapies
![dpp 4 and glp 1 GLP-1 receptor agonists or DPP-4 inhibitors: How to guide the clinician? dpp-4_inhibitors [TUSOM | Pharmwiki]](https://i.ytimg.com/vi/YRCELHdfGFI/maxresdefault.jpg)