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Description
A parallel line of work frames Alzheimers disease as a state of central insulin resistance, sometimes called type 3 diabetes, in which GLP-1R agonism restores neuronal insulin signalling, improves mitochondrial function, and reduces oxidative stress
Conclusions and future directions Obesity in women is a global problem

2021;911 doi: 10.1016/j.ejphar.2021.174482
While they possess more mitochondria than white adipocytes, their mitochondrial content is less than that of brown adipocytes

Tirzepatide addresses the limitations of standalone GIP therapy in diabetes by combining GIPR and GLP-1 receptor (GLP-1R) agonism, leveraging their complementary mechanisms [23]
