does glp-1 cause you to lose muscle matters: the effects of medically induced weight loss on skeletal muscle GLP-1 Side Effects Long Term:

doi: 10.2147/NDT.S260160 161 MaDLChenFQXuWJYueWZYuanGYangY

Genetic differences in GLP-1 receptor expression and function can affect how well these medications work

Oral formulations Oral semaglutide : The first and only oral GLP-1 drug, offering an alternative for patients who prefer not to use injections

Figure 2: Pathogenesis of type 1 and type 2 diabetes

For mild local injection site reactions : Apply a cold compress to the affected area to reduce swelling and discomfort Avoid rubbing or scratching the injection site Monitor the reaction over 2448 hours for any worsening Contact your GP or diabetes specialist nurse if symptoms persist beyond 72 hours, spread beyond the injection site, or cause significant discomfort If symptoms are mild and self-limiting without systemic features, continue to monitor but discuss with your healthcare team before making any treatment changes For moderate systemic reactions (such as widespread hives or mild facial swelling without breathing difficulty): Stop using the medication immediately and do not take further doses Contact your GP urgently or call NHS 111 for advice Take an oral antihistamine if available and previously tolerated (such as cetirizine or loratadine) Seek same-day medical assessment to determine whether the medication should be discontinued and to discuss alternative treatment options For severe reactions or suspected anaphylaxis (difficulty breathing, throat swelling, collapse, or rapid symptom progression): Call 999 immediately and request an ambulance Use an adrenaline auto-injector if one has been prescribed and you have been trained in its use Lie flat with legs elevated (unless breathing is difficult, in which case sit upright) Do not attempt to drive yourself to hospital Inform paramedics and hospital staff about the GLP-1 agonist and timing of the last dose Following any allergic reaction, it is important to report the event to your healthcare team