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Description
Oral semaglutide 25 mg (Wegovy pill) showed 13.6 to 16.6% loss over 64 weeks in the OASIS 4 trial
While early onset may indicate physiological adaptation to receptor activation, detection bias from intensified early monitoring cannot be excluded
Ensure you have reached therapeutic doses before concluding a medication does not work
Where standard weight loss protocols use doses of 2.5 mg to 15 mg weekly, microdosing protocols use doses of 0.5 mg to 1.5 mg weekly
While some early signals suggested a possible association with thyroid neoplasms, further investigation revealed potential detection bias
