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When to Consider Dose Modifications Dose adjustment should be considered only after optimizing all other factors
The early data is encouraging, but promising in trials is not the same as approved and validated. It is not an available, approved weight-loss treatment the way semaglutide is
2326 Glitazones for type 2 diabetes therapy have been linked to serious side effects such as fluid retention, congestive heart failure, weight gain, bone loss, and increased risk of bladder cancer

Characterization of signal bias at the GLP-1 receptor induced by backbone modification of GLP-1

doi: 10.1038/embor.2012.174 156 DingFLiHHZhangSSolomonNMCamperSACohenPet al
