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Exendin-4 protects against postmyocardial infarction remodeling via specific actions on inflammation and the extracellular matrix

However, clinical trials and real-world evidence consistently show that weight reduction with GLP-1RAs is accompanied by decrease in lean body mass, raising concern in patients already predisposed to muscle wasting and underscoring the need for integrated management strategies

In type 2 diabetes patients, it reduces HbA1c by approximately 2.1 percentage points and lowers body weight by an average of 6.2 kg

PhysiologyEndocrinology Metabolism 305 (2), E229E236